Yes, Nitazoxanide 500 mg may have side effects, although they are generally mild and well-tolerated. Common side effects of nitazoxanide may include gastrointestinal discomfort, such as nausea, vomiting, diarrhea, and abdominal pain. These side effects are usually temporary and resolve on their own. Allergic reactions to nitazoxanide are rare but can occur, leading to symptoms like rash, itching, and difficulty breathing. In very rare cases, Nizonide 500 may cause liver-related adverse effects, characterized by elevated liver enzyme levels. Patients should promptly report any severe or persistent side effects to their healthcare provider. Overall, nitazoxanide is considered safe and effective when used appropriately under medical supervision.